Lytic bone disease as the presenting feature of Philadelphia-positive monosomy 7 myelodysplasia progressing to acute myeloid leukaemia

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• 作者：D. Tucker^a ; ^{tucks60@gmail.com} ; M.S. Hamilton^a ; J.P. Kerr^a ; C. Wickham^b ; H. Hunter^c
• 关键词：AML ; Acute myeloid leukaemia ; CML ; Chronic myeloid leukaemia ; IPSS ; International Prognostic Scoring System ; CD ; Cluster of differentiation ; CT ; Computerised tomography ; FLAG-Ida ; Fludarabine ; cytarabine and idarubicin
• 刊名：Gene
• 出版年：2012
• 期刊代码：73_03781119
• 类别：bio
• 出版时间：15 June, 2012
• 卷：501
• 期：2
• 页码：219-221
• 文件大小：317 K

摘要

We describe an unusual case of Philadelphia-positive, monosomy 7 myelodysplasia progressing to acute myeloid leukaemia in a 53 year old male who presented with bone-pain and B-symptoms and was found to have diffuse osteolytic lesions. Molecular genetic analysis revealed both b3a2 and e1a2 t(9;22) transcripts. Cytogenetic analysis was an additional useful test in determining the course and management of an atypical BCR-ABL positive myelodysplasia.