Biocidal activity of some Mannich base cationic derivatives

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• 作者：Nabel A. Negm ; Salwa M.I. Morsy and Medhat M. Said
• 关键词：Mannich base ; Surface tension ; Interfacial tension ; Critical micelle concentration ; Effectiveness ; Efficiency ; Surface pressure ; Minimum surface area ; Emulsification power ; Free energy ; Adsorption ; Micellization ; Antibacteria ; Antifungi ; Antiyeast ; Bacter
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2005
• 期刊代码：9_09680896
• 类别：ch
• 出版时间：2005
• 卷：13
• 期：21
• 页码：5921-5926
• 文件大小：120 K

摘要

A novel series of cationic surfactants was prepared based on Mannich base (produced from the condensation of piperidine and/or morpholine as secondary amine and paraformaldehyde in the presence of 8-hydroxyquinoline). The chemical structures of the synthesized cationic surfactants were confirmed using elemental analyses, FTIR spectroscopy and ¹H NMR. Surface activities of the prepared surfactants were measured including: surface tension (γ), critical micelle concentration (CMC), effectiveness (π_CMC), efficiency (Pc₂₀), maximum surface excess (Γ_max), minimum surface area (A_min), interfacial tension (γ_IT), emulsification power and foaming power at 25 °C. The structural influences on their surface activities and adsorption free energy were discussed. The synthesized cationic surfactants were evaluated for their biocidal activity towards Gram +ve bacteria (Staph. Cocu., Bacillus), Gram −ve bacteria (Salmonella, E. coli), fungi (A. terrus., A. flav.) and yeast (Candida) at 1.0, 2.5 and 5.0 mg/mL, respectively. The target compounds showed good inhibition towards Gram +ve bacteria, Gram −ve bacteria and yeast. Meanwhile, excellent fungicidal results were obtained against the various types of fungi under investigation.