The purpose of the present study was to compare tiapride- and pyridostigmine-based pretreatment strategies, either alone or in combination with pralidoxime reactivation, by using a prospective, non-blinded study in a rat model of acute high-dose paraoxon exposure.
Groups 1–6 received 1 μMol paraoxon (≈ LD75) groups 2–6 received in addition:
G2
50 μMol tiapride 30 min before paraoxon
G3
50 μMol tiapride 30 min before paraoxon and 50 μMol pralidoxime 1 min after paraoxon
G4
1 μMol pyridostigmine 30 min before paraoxon
G5
1 μMol pyridostigmine 30 min before paraoxon and 50 μMol pralidoxime 1 min after paraoxon
G6
50 μMol pralidoxime 1 min after paraoxon
Mortality data were compared using Kaplan–Meier plots and logrank tests. Mortality is statistically significantly influenced by all treatment strategies. Tiapride pretreatment followed by pralidoxime treatment (G3) is aux par with pyridostigmine pretreatment followed by pralidoxime treatment (G5). Tiapride pretreatment only (G2) is inferior to pyridostigmine pretreatment only (G4). The best results are achieved with pyridostigmine pretreatment only or pralidoxime treatment only (G4 and G6).