Brain-derived neurotrophic factor Val66Met polymorphism and obsessive-compulsive symptoms in Egyptian schizophrenia patients

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• 作者：Haytham M. Hashim^a ; Nagy Fawzy^a ; Mohab M. Fawzi^a ; Rehab A. Karam^b ; ^{rehab_atta@yahoo.com}
• 关键词：Schizophrenia ; Obsessive-compulsive symptoms ; Brain-derived neurotrophic factor
• 刊名：Journal of Psychiatric Research
• 出版年：2012
• 期刊代码：169_00223956
• 类别：med
• 出版时间：June, 2012
• 卷：46
• 期：6
• 页码：762-766
• 文件大小：146 K

摘要

lass="h4">Background

Brain-derived neurotrophic factor (BDNF) has been advanced as a candidate gene for schizophrenia. BDNF promote the function and growth of 5-HT neurons in the brain and modulate the synaptic plasticity of DRD3-secreting neurons in the striatum, suggesting involvement of BDNF in the mediation of obsessive-compulsive disorder.

lass="h4">Objectives

To test the hypothesis that the BDNF Val66Met polymorphism influence obsessive-compulsive symptoms (OCS) in schizophrenia, we examined the association between the BDNF Val66Met genotypes and OCS in a group of patients with schizophrenia.

lass="h4">Methods

320 schizophrenia patients were assessed using the Yale-Brown Obsessive-Compulsive Scale (YBOCS). BDNF Val66Met polymorphism was genotyped using PCR-RFLP method, and severity of OCS were compared between the genotype groups.

lass="h4">Results

Out of the 320 schizophrenia patients, 120 patients (37.5%) had significant OCS. There was a significant excess of valine allele in the schizophrenia with-OCS group compared to the without-OCS group. The mean YBOCS scores were significantly different among the three genotype groups. Val/Val homozygote patients had higher mean YBOCS scores compared to Val/Met genotype (p聽=聽0.0001) as well as to the Met/Met homozygote group (p聽=聽0.003).

lass="h4">Conclusion

Our data suggested an association between BDNF Val66Met polymorphism and OCS in Egyptian schizophrenia patients.