Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation

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• 作者：Rieko Ajima ; Toru Akiyama ; Michihiko Usui ; Mitsuhiro Yoneda ; Yutaka Yoshida ; Takahisa Nakamura ; Osamu Minowa ; Masaki Noda ; Sakae Tanaka ; Tetsuo Noda ; Tadashi Yamamoto
• 关键词：Bone mass ; Osteoclast ; Gene targeting ; tob Family ; Vitamin D₃
• 刊名：FEBS Letters
• 出版年：2008
• 期刊代码：70_00145793
• 类别：bio
• 出版时间：16 April 2008
• 卷：582
• 期：9
• 页码：1313-1318
• 文件大小：227 K

摘要

Mice lacking tob2, a member of the antiproliferative family genes, had decreased bone mass, and the number of osteoclasts differentiated from bone marrow cells was increased. Overexpression of Tob2 in stromal cells repressed vitamin D₃-induced osteoclasts formation. Furthermore, expression of RANKL mRNA in stromal cells was increased in the absence of Tob2 and decreased in the presence of Tob2. Tob2 interacted with vitamin D₃ receptor (VDR), which suggests its involvement in vitamin D₃ receptor-mediated regulation of transcription. Because VDR regulates RANKL expression, our data suggest that Tob2 negatively regulates formation of osteoclasts by suppressing RANKL expression through its interaction with VDR.