Insulin-like growth factor-1 cytokines cross-talk in type 1 diabetes mellitus: Relationship to microvascular complications and bone mineral density

详细信息	查看全文 | 推荐本文 |

• 作者：Mohammed A. AboElAsrar^a ; ^{mohamedaboelasrar2@yahoo.com} ; Nancy S. Elbarbary^a ; ^{nancy_elbarbary@yahoo.com} ; Dina E. Elshennawy^b ; ^{doc.dina@hotmail.com} ; Amin M. Omar^a ; ^{dramin_omar@yahoo.com}
• 关键词：Insulin-like growth factor-1 ; Interleukin 6 ; Interleukin 8 ; Bone mineral density ; Type 1 diabetes
• 刊名：Cytokine
• 出版年：2012
• 期刊代码：97_10434666
• 类别：imm
• 出版时间：July, 2012
• 卷：59
• 期：1
• 页码：86-93
• 文件大小：275 K

摘要

<h4 class="h4">Objectiveh4>This study was designed to investigate the association between inflammatory cytokines (IL-8, IL-6) and IGF-1 levels in relation to metabolic control, microvascular complications and bone mineral density (BMD) in a cohort of Egyptian adolescents with T1DM.<h4 class="h4">Research design and methodsh4>

Sixty patients with T1DM (mean age was 14.67 卤 1.53 years, mean disease duration was 6.87 卤 1.25 years) and 40 controls participated in the study. Thirty-six patients (60%) had poor glycemic control (HbA1C measurements 猢?%) while the rest (n = 24%, 40%) had good glycemic control (HbA1C measurements <8%). Serum IL-6, IL-8, and IGF-1 levels were measured. Whole body DXA scan were assessed. Total body and lumbar spine (L2-L4) bone mineral content (BMC, g) and bone area (BA, cm²) were measured by DXA scan, bone mineral density (BMD, g/cm²) was calculated by BMC/BA.<h4 class="h4">Resultsh4>

Patients with T1DM had higher IL-6 and IL-8 levels with lower IGF-1 than healthy controls (P < 0.001). Within the T1DM patients those with poor glycemic control had higher IL-6 and IL-8 as well as lower IGF-1 and total BMD than those with good glycemic control (P < 0.001 for all). IL-6 and IL-8 were negatively correlated with IGF-1 (P = 0.005 and 0.021, respectively). The peripheral neuropathy rate was also greater in T1DM patients with poor glycemic control (P = 0.02). Presence of nephropathy or retinopathy was not different (P = 0.69 and 0.50, respectively).<h4 class="h4">Conclusionh4>

High IL-6, IL-8 with low IGF-1 levels are found in adolescents with T1DM. It seems that poor glycemic control exacerbates inflammatory cytokines, increases peripheral neuropathy, and decreases bone mineral density.