Preparation of strongly fluorescent silica nanoparticles of polyelectrolyte-protected cadmium telluride quantum dots and their application to cell toxicity and imaging

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• 作者：Jian-hua Tang^a ; ¹ ; Lian Xie^a ; ¹ ; Bin Zhang^a ; Ting Qiu^a ; Bin Qi^a ; ^b ; Hong-ping Xie^a ; ^{hpxie@suda.edu.cn}
• 关键词：Polyelectrolyte-protected CdTe quantum dots ; Strong fluorescence silica nanoparticles ; Reverse microemulsion method ; Cellular toxicity ; Cellular imaging
• 刊名：Analytica Chimica Acta
• 出版年：2012
• 期刊代码：2_00032670
• 类别：ch
• 出版时间：30 March, 2012
• 卷：720
• 期：Complete
• 页码：112-117
• 文件大小：606 K

摘要

Based on the polyelectrolyte-protected CdTe quantum dots (QDs), which were prepared by self-assembling of QDs and poly-diallyldimethylammonium chloride (PDADMAC) in the help of electrostatic attraction, the strong fluorescence silica nanoparticles (QDs-PDADMAC@SiO₂) have been prepared via a water-in-oil reverse microemulsion method. Transmission electron microscopy and Zeta potential analysis were used to characterize the as-prepared nanoparticles. All of the particles were almost spherical and there is a uniform distribution of the particle size with the average diameter about 25 nm. There is a large Zeta potential of 鈭?5.07 mV which is necessary for good monodispersity of nanoparticles solution. As compared with the QDs coated by SiO₂ (QDs@SiO₂), the QDs-PDADMAC@SiO₂ nanoparticles have much stronger fluorescence, and their fluorescence stability could be obviously improved. Moreover, QDs-PDADMAC@SiO₂ exhibits good biological compatibility which promotes their application in cellular imaging.