Development of a Quercetin-loaded nanostructured lipid carrier formulation for topical delivery

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• 作者：Guo Chen-yu^a ; ^b ; ¹ ; Yang Chun-fen^a ; ¹ ; Li Qi-lu^c ; Tan Qi^a ; Xi Yan-wei^a ; Liu Wei-na^d ; Zhai Guang-xi^a ; ^{professorgxzhai@yahoo.cn}
• 关键词：QT ; Quercetin ; QT-NLCs ; Quercetin-loaded nanostructured lipid carriers
• 刊名：International Journal of Pharmaceutics
• 出版年：2012
• 期刊代码：24_03785173
• 类别：pha
• 出版时间：1 July, 2012
• 卷：430
• 期：1-2
• 页码：292-298
• 文件大小：892 K

摘要

The main objective of this study was to evaluate the potential of Quercetin-loaded nanostructured lipid carriers (QT-NLCs) as a topical delivery system. QT-NLCs were prepared by the method of emulsion evaporation-solidification at low temperature. The average entrapment efficiency and drug loading of the optimized QT-NLCs were 89.95 卤 0.16%and 3.05 卤 0.01%, respectively. Under the transmission electron microscope, the nanoparticles were spherically shaped. The average particle size was 215.2 nm, the zeta potential was 鈭?0.10 卤 1.22 mV and pH value of QT-NLCs system was 4.65. Topical delivery of QT in the form of NLCs was investigated in vitro and in vivo. The results showed that QT-NLCs could promote the permeation of QT, increase the amount of QT retention in epidermis and dermis, and enhance the effect of anti-oxidation and anti-inflammation exerted by QT. Then the mechanism of NLCs for facilitating drug penetration was further investigated through histological sections. In conclusion, NLCs could be a promising vehicle for topical delivery of QT.