Synthesis of modified uracil and cytosine nucleobases using a microwave-assisted method

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• 作者：Laxmi Narayana Burgula ; K. Radhakrishnan ; Lal Mohan Kundu ; ^{lmkundu@iitg.ernet.in} ; ^{kundu77@gmail.com}
• 关键词：Nucleobases ; Pyrimidine ; Lewis acid ; Microwave ; DNA damage
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：23 May, 2012
• 卷：53
• 期：21
• 页码：2639-2642
• 文件大小：2112 K

摘要

Modified nucleobases and nucleic acids have found many biological and pharmaceutical applications. Here we report a microwave-directed synthesis of a variety of modified uracil and cytosine nucleobases with high yields under solvent-free conditions. The reaction yields were further improved by addition of Lewis acid. The crystal structures of 5-isopropyl-6-methyluracil and 6-phenyluracil were also determined.