Collagen adsorption on quercetin loaded polycaprolactone microspheres: Approach for 鈥渟tealth鈥?implant

详细信息	查看全文 | 推荐本文 |

• 作者：Venkatachalam Natarajan¹ ; Pandian Saravanakumar¹ ; Balaraman Madhan ; ^{bmadhan76@yahoo.co.in}
• 关键词：Adsorption ; Collagen ; Implants ; Microspheres ; Solid surface
• 刊名：International Journal of Biological Macromolecules
• 出版年：2012
• 期刊代码：62_01418130
• 类别：abs
• 出版时间：1 May, 2012
• 卷：50
• 期：4
• 页码：1091-1094
• 文件大小：463 K

摘要

We recently experimented with collagen coating on the surface of quercetin loaded polycaprolactone microspheres by simple adsorption technique to mimic extra cellular matrix and reduce immune or inflammatory responses at the site of implants. The collagen immobilization on polymeric scaffold surfaces through various surface modification techniques was the current scenario to improve bio-integration of the polymers with the in vivo system. Nevertheless, it requires other chemicals or processing methods to modify the surface of polymers to immobilize the collagen covalently. Here protein adsorption principle is used for the coating of collagen onto the surface of solid microspheres and characterized. Optical, ATR-FTIR, SEM analysis confirm collagen coating. The reduction in burst release of the quercetin from the PCL microspheres further confirms its presence and role in the controlled release. The results indicate that the adsorption technique can be the simple strategy to coat collagen on the surface of polyester implants to develop stealth implant in shorter time with low cost technology.