AML1 amplification in a case of childhood acute lymphoblastic leukemia

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• 作者：Morel ; Fré ; dé ; ric ; Herry ; Angè ; le ; Le Bris ; Marie-José ; e ; Douet-Guilbert ; Nathalie ; et. al.
• 刊名：Cancer Genetics and Cytogenetics
• 出版年：2002
• 期刊代码：43_01654608
• 类别：med
• 出版时间：September, 2002
• 卷：137
• 期：2
• 页码：142-145
• 文件大小：151 K

摘要

We report an 8-year-old girl with B-cell acute lymphoblastic leukemia (ALL). The blast cell karyotype at diagnosis included a marker chromosome revealed by fluorescence in situ hybridization to be a derivative of chromosome 21. A high level amplification of the AML1 gene was identified, but it disappeared upon complete remission. This rare but recurrent abnormality warrants research of B-cell ALL, especially when a marker chromosome is present in the blast cell karyotype.