One-lung overventilation does not induce inflammation in the normally ventilated contralateral lung
- 作者：Isaac Almendros ; Patricia T. Gutierrez ; Daniel Closa ; Daniel Navajas ; Ramon Farre
- 关键词：Mechanical ventilation ; Lung injury ; Lung edema ; Lung over stretch ; High volume ventilation ; Differential ventilation
- 刊名：Respiratory Physiology & Neurobiology
- 出版年：2008
- 期刊代码：185_15699048
- 类别：bio
- 出版时间：30 June 2008
- 卷：162
- 期：1
- 页码：100-102
- 文件大小：216 K
摘要
The aim was to assess whether induction of ventilator-induced lung injury (VILI) in one lung triggers a concomitant inflammatory response in the normally ventilated contralateral lung. To this end, a differential ventilator was used in 6 rats. One lung was normally ventilated (3.5 ml/kg b.w.) and the contralateral lung was overstretched (15 ml/kg b.w.). Six control rats were normally ventilated (3.5 ml/kg b.w. each lung). After 3 h, edema and gene expression of MIP-2 in the lung, and plasma and liver TNF-
were assessed. Overexpression of MIP-2 and edema were found in the overventilated lung but not in the normally ventilated contralateral lung. No detectable levels of circulating and liver TNF- were detected. These data do not support the hypothesis of an early positive feedback in the lung inflammation during the mechanical ventilation.
were assessed. Overexpression of MIP-2 and edema were found in the overventilated lung but not in the normally ventilated contralateral lung. No detectable levels of circulating and liver TNF- were detected. These data do not support the hypothesis of an early positive feedback in the lung inflammation during the mechanical ventilation.