- 作者：S. Sanz Viedma<sup>asup><sup> ; sup><sup>salomesanzv@gmail.comsup> ; I. Borrego Dorado<sup>asup> ; J.R. Rodrí ; guez Rodrí ; guez<sup>asup> ; E. Navarro Gonzá ; lez<sup>bsup> ; R. Vá ; zquez Albertino<sup>asup> ; R. Ferná ; ndez Ló ; pez<sup>asup> ; A. Agudo Martí ; nez<sup>asup>
- 关键词：Cá ; ncer de tiroides ; Antitiroglobulina ; Tomografí ; a por emisió ; n de positrones ; 18F-fluorodeoxiglucosa
- 刊名：Revista Espa帽ola de Medicina Nuclear
- 出版年：2011
- 期刊代码：pca315_02126982
- 类别：med
- 出版时间：March-April 2011
- 卷：30
- 期：2
- 页码：77-82
- 文件大小：569 K
ss="h4">Aim
To evaluate the utility of <sup>18Fsup>FDG-PET for patients diagnosed of differentiated thyroid carcinoma who present risk of disease and invaluable levels of thyroglobulin (Tg) by the presence of antibodies antithyroglobulin (AbTg).
ss="h4">Material and methods
Retrospective study of 7 women of 40 years old and histological diagnosis of differentiated thyroid cancer (7 papillary tumours) that were sent to our department for the accomplishment of<sup>18Fsup>FDG-PET study because of suspicion of disease, due to <sup>131sup>I negative and high levels of AbTg, between the year 2002 and 2007. 11 PET scans were obtained after the intravenous injection of 370-434 MBq of <sup>18Fsup>FDG in normoglycemia conditions and previous administration of muscle relaxant, hydration and diuretic. The results of <sup>18Fsup>FDG-PET scans were confirmed by pathologic examination or clinical outcome and radiographic examination for more than 24 months.
ss="h4">Results
The prevalence of recurrence in our population was 57.14%. All patients presented levels of Tg lower than 3 ng/dl and AbTg superior to 200 UI/ml. Three patients had precedent thyroiditis. Out of 11 scans performed 3 of them were negative and 8 cases were found positive. It ruled out the existence of disease in three patients and localized the presence of recurrence in 4 patients.
ss="h4">Conclusion
<sup>18Fsup>FDG-PET
CONCLUSION: 18F-FDG-PET is a useful diagnostic tool for the detection of recurrence as well as to rule out the existence of disease with a high accuracy, in patients with differentiated thyroid carcinoma with <sup>131sup>I whole body scan negative but with pathological elevation of antithyroglobulin antibodies.