Cisplatin and dimethyl sulfoxide react to form an adducted compound with reduced cytotoxicity and neurotoxicity

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• 作者：Stephanie J. Fischer ; Linda M. Benson ; Abdul Fauq ; Stephen Naylor ; Anthony J. Windebank
• 关键词：Cisplatin ; DMSO ; Neurotoxicity ; Cytotoxicity ; Mass spectroscopy
• 刊名：Neurotoxicology
• 出版年：2008
• 期刊代码：35_0161813x
• 类别：pha
• 出版时间：May 2008
• 卷：29
• 期：3
• 页码：444-452
• 文件大小：753 K

摘要

We present work that demonstrates that cisplatin reacts rapidly with dimethyl sulfoxide (DMSO) in solution and identify the structure and reactivity of the resulting compound.