The spinal precerebellar nuclei: Calcium binding proteins and gene expression profile in the mouse

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• 作者：YuHong Fu^a ; ¹ ; Gulgun Sengul^b ; ¹ ; George Paxinos^a ; ^c ; Charles Watson^a ; ^d ; ^{c.watson@curtin.edu.au}
• 关键词：2Cb&ndash ; 10Cb ; lobules 2&ndash ; 10 of the cerebellar vermis ; 6-8Sp ; spinal laminae 6&ndash ; 8 ; C ; cervical ; Cb ; calbindin-D-28K ; CBPs ; calcium binding proteins ; CC ; central canal ; CeCv ; central cervical nucleus ; Cr ; calretinin ; Crus1 ; Crus1 of the ansiform
• 刊名：Neuroscience Letters
• 出版年：2012
• 期刊代码：52_03043940
• 类别：neu
• 出版时间：19 June, 2012
• 卷：518
• 期：2
• 页码：161-166
• 文件大小：1166 K

摘要

We have localized the spinocerebellar neuron groups in C57BL/6J mice by injecting the retrograde neuronal tracer Fluoro-Gold into the cerebellum and examined the distribution of SMI 32 and the calcium-binding proteins (CBPs), calbindin-D-28K (Cb), calretinin (Cr), and parvalbumin (Pv) in the spinal precerebellar nuclei. The spinal precerebellar neuron clusters identified were the dorsal nucleus, central cervical nucleus, lumbar border precerebellar nucleus, lumbar precerebellar nucleus, and sacral precerebellar nucleus. Some dispersed neurons in the deep dorsal horn and spinal laminae 6-8 also projected to the cerebellum. Cb, Cr, Pv, and SMI 32 were present in all major spinal precerebellar nuclei and Pv was the most commonly observed CBP. A number of genes expressed in hindbrain precerebellar nuclei are also expressed in spinal precerebellar groups, but there were some differences in gene expression profile between the different spinal precerebellar nuclei, pointing to functional diversity amongst them.