A simple and fast method for the preparation of n.c.a. 2-[¹⁸F]F-A85380 for human use

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• 作者：J. Schmaljohann ; D. Gü ; ndisch ; M. Minnerop ; A. Joe ; J. Bucerius ; C. Dittmar ; F. Jessen ; S. Guhlke and U. Wü ; llner
• 关键词：Nicotinic acetylcholine receptor ; Fluor-18 ; 2-¹⁸F-A85380 ; PET
• 刊名：Applied Radiation and Isotopes
• 出版年：2005
• 期刊代码：6_09698043
• 类别：ce
• 出版时间：2005
• 卷：63
• 期：4
• 页码：433-435
• 文件大小：170 K

摘要

2-[¹⁸F]F-A85380 is the first subtype selective PET-radiotracer to visualize the distribution of α₄β₂ nicotinic acetylcholine receptors in human brain in vivo. We investigated a fast and safe automated production of 2-[¹⁸F]F-A85380 by purification of the BOC-protected intermediate product with a combination of solid phase extraction cartridges. After deprotection, adjustment of the pH and sterile filtration n.c.a. 2-[¹⁸F]F-A85380 was applicable for the use in human studies with a high specific activity and an overall radiochemical yield of 55%in 35 minutes.