• 作者：José ; Antonio Costa^a ; Enrique Rodilla^a ; ^b ; Joaquí ; n Cardona^a ; ^b ; Carmen Gonzá ; lez^c ; José ; Marí ; a Pascual^a ; ^b ; ^d ; ^{pascual_jma@gva.es}
• 关键词：Sí ; ndrome Metab&oacute ; lico. Enfermedad cardiovascular. Factores de riesgo cardiovascular
• 刊名：Medicina Cl篓陋nica
• 出版年：2012
• 期刊代码：pca254_00257753
• 类别：med
• 出版时间：7 July, 2012
• 卷：139
• 期：4
• 页码：150-156
• 文件大小：350 K

Background and objectives

The aim of this study was to assess the impact of metabolic syndrome (MS) as a predictor of cardiovascular events (CVE) in hypertensives in primary prevention.

Patients and methods

This retrospective study involved 2410 non-diabetic, hypertensive patients (52%women, 43%with MS), without previous CVE. The total follow-up was 13096 patient-years with a median of 4,5 years (IIQ; 2,2-7,3).

Results

Patients with metabolic syndrome did not have more risk of CVE (HR 1,19; CI 95%:0,89-1,58; p = 0,292), 183 patients had a CVE, 88 in patients with MS (15,4; CI 95%:12,4-19,0 patients-years), and 95 in patients without MS (13,0; CI 95%:10,5-15,9 patients/years) (p = 0,279). In a multivariate analysis corrected for other factors, only age (HR 1,08; CI 95%: 1,07-1,10; p = 0,001), male gender (HR 1,77; CI 95%: 1,27-2,45; p = 0,001), smoking (HR 2,95; CI 95%: 2,01-4,34; p = 0,001) at the beginning, and values of systolic arterial pressure 鈮?60 mm Hg (HR 1,83; CI 95%: 1,17-2,89; p = 0,009) and cholesterol-low density lipoproteins 鈮?60 mg/dl (HR 1,58; CI 95%: 1,05-2,38; p = 0,029) during the follow-up, were associated with new CVE.

Conclusions

In hypertensive non-diabetic patients in primary prevention the diagnosis of metabolic syndrome did not add any significant prediction about future CVE over the traditional risk factors. Systolic arterial pressure 鈮?60 mm Hg and cholesterol-low density lipoproteins 鈮?60 mg/dl, respectively, during the follow up were factors related to new CVE.