Decreased levels of GABA in the inferior colliculus of the epilepsy-prone hamster (GPG/Vall)

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• 作者：Veró ; nica Fuentes-Santamar&#xed ; a ; Juan Carlos Alvarado ; Antonio S. Herranz ; Natividad Garc&#xed ; a-Ataré ; s ; Dolores E. Ló ; pez
• 关键词：AGS ; Animal model ; Amino acid ; Densitometric analysis
• 刊名：Epilepsy Research
• 出版年：2008
• 期刊代码：87_09201211
• 类别：med
• 出版时间：May 2008
• 卷：79
• 期：2-3
• 页码：224-227
• 文件大小：522 K

摘要

The results show that: 1) 25%of the IC neurons are GABAergic; 2) there are more GABAergic neurons in the central nucleus of the IC than previously estimated; 3) GABAergic neurons are larger than non-GABAergic; 4) GABAergic neurons receive less GABA and glycine puncta than non-GABAergic; 5) differences across frequency regions are minor, except that the non-GABAergic neurons from high frequency regions are larger than their counterparts in low frequency regions; 6) differences within the laminae are greater along the dorsomedial–ventrolateral axis than along the rostrocaudal axis; 7) GABA and non-GABAergic neurons receive different numbers of puncta in different IC subdivisions; and 8) GABAergic puncta are both apposed to the somata and in the neuropil, glycinergic puncta are mostly confined to the neuropil.