- 作者：Matteo Nicola Dario Di Minno ; dario.diminno@hotmail.it ; Roberta Lupoli ; Nicola Macarone Palmieri ; Anna Russolillo ; Agostino Buonauro ; Giovanni Di Minno
- 关键词：aspirin resistance ; platelet turnover ; pairs of aggregating agents ; stored platelets ; mouse anti-thrombotic assay ; diabetic angiopathy
- 刊名：Thrombosis Research
- 出版年：2012
- 期刊代码：247_00493848
- 类别：med
- 出版时间：March, 2012
- 卷：129
- 期：3
- 页码：341-344
- 文件大小：146 K
The evidence of an incomplete inhibition of platelet function by aspirin, despite doses of the drug proved to be clinically effective are employed, was first reported in the 鈥?0s, in studies devoted to platelet turnover. Based on this concept, the possibility of monitoring the entry of newly formed platelets into the circulation after aspirin ingestion was documented by measuring the return of thromboxane biosynthesis by platelets challenged in vitro by pairs of aggregating agents. The data obtained showed that platelets with intact cyclooxygenase activity could be detected into the circulation of control individuals as early as 4-6 hrs after aspirin ingestion, but at shorter time intervals in diabetic angiopathy. In the latter setting, it was concluded that 鈥渟chedules of aspirin which may suffice in normals are not effective in patients with diabetic angiopathy, presumably because these patients have a high rate of entry of new platelets into the circulation鈥?
As many as 25 years after its original publication, the clinical relevance of an accelerated platelet turnover as to 鈥渁spirin resistance鈥?has been confirmed and extended to other clinical settings at high risk of ischemic events. Newer aspirin dosing and scheduling, tailored at reducing the individual patient risk related to an incomplete inhibition of platelet function by a standard aspirin dose should now be defined.