Confocal optics microscopy for biochemical and cellular high-throughput screening

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• 作者：Zemanová ; Lenka ; Schenk ; Andreas ; Valler ; Martin J. ; Nienhaus ; G. Ulrich ; Heilker ; Ralf
• 关键词：confocal microscopy ; fluorescence correlation spectroscopy ; photon counting histogram ; cellular screening ; Drug Discovery ; Techniques & Methods ; Pharmaceutical Science
• 刊名：Drug Discovery Today
• 出版年：2003
• 期刊代码：29_13596446
• 类别：imm
• 出版时间：December 1, 2003
• 卷：8
• 期：23
• 页码：1085-1093
• 文件大小：490 K

摘要

In this review, fluorescence fluctuation spectroscopy techniques used in biochemical drug discovery and the advantages of confocal optics for cellular imaging are described. Instrumentation for both applications in an HTS environment is presented.