IL-7 in human health and disease

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• 作者：Wangko Lundströ ; m¹ ; ^{lundstromwp@mail.nih.gov} ; Natasha M. Fewkes² ; ^{fewkesnm@mail.nih.gov} ; Crystal L. Mackall ; ^{mackallc@mail.nih.gov} ; ^{cm35c@nih.gov}
• 关键词：Interleukin-7 ; Interleukin-7 receptor ; Cancer ; Autoimmunity
• 刊名：Seminars in Immunology
• 出版年：2012
• 期刊代码：105_10445323
• 类别：imm
• 出版时间：June, 2012
• 卷：24
• 期：3
• 页码：218-224
• 文件大小：419 K

摘要

IL-7 plays many essential roles in human health and disease. Congenital deficiencies in IL-7 signaling result in profound immunodeficiency, polymorphisms in IL7R伪 modulate susceptibility to autoimmune disease, and acquired somatic activating mutations in IL7R伪 contribute to neoplastic transformation in B cell and T cell leukemia. In response to lymphopenia, IL-7 accumulates to supranormal levels, which alters T cell homeostasis by augmenting T cell reactivity toward self and cognate antigens. This physiologic response is now routinely exploited to improve the efficacy of adoptive cell therapies for cancer. Clinical trials of recombinant IL-7 have demonstrated safety and potent immunorestorative effects, and current studies are investigating whether rhIL-7 therapy can improve outcomes in chronic viral infection and in the context of cancer immunotherapies. Building upon the large fund of knowledge regarding the basic biology of IL-7, this review will discuss the many and varied roles of IL-7 in human health and disease.