Unmedicated, remitted patients with major depression have decreased serum immunoglobulin A

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• 作者：Philip W. Gold^a ; ^{philipgold@mail.nih.gov} ; Maria G. Pavlatou^a ; ^{pavlatom@mail.nih.gov} ; Paul J. Carlson^b ; ^{paul.carlson@hsc.utah.edu} ; David A. Luckenbaugh^c ; ^{luckenbd@mail.nih.gov} ; Rene Costello^d ; ^{rcostello@mail.nih.gov} ; Omer Bonne^e ; ^{BONNE@hadassah.org.il} ; Gyorgy Csako^d ; ^{LMCSJ@aol.com} ; Wayne C. Drevets^f ; ^{wdrevets@laureateinstitute.org} ; Alan T. Remaley^d ; ^{aremaley1@cc.nih.gov} ; Dennis S. Charney^g ; ^{dennis.charney@mssm.edu} ; Alexander Neumeister^h ; ¹ ; ^{alexander.neumeister@mssm.edu} ; Mitchel A. Kling^a ; ⁱ ; ^j ; ¹ ; ^{Mitchel.Kling@uphs.upenn.edu}
• 关键词：Major depression ; Immunoglobulin IgA ; Proinflammatory state
• 刊名：Neuroscience Letters
• 出版年：2012
• 期刊代码：52_03043940
• 类别：neu
• 出版时间：27 June, 2012
• 卷：520
• 期：1
• 页码：1-5
• 文件大小：287 K

摘要

Patents with major depression have evidence of a proinflammatory state with consistent elevations in acute phase proteins and in the levels of inflammatory mediators such as interleukin-6 and tumor necrosis factor-伪. We report here a study of the serum levels of immunoglobulin A (IgA) in medication-free patients with major depression in the remitted state (ruMDD). Selective IgA deficiency is the most common form of immunoglobulin abnormality, and is often associated with a higher than expected incidence of proinflammatory and autoimmune phenomena. We measured serum IgG, IgM, and IgA in 28 ruMDD patients and 27 healthy subjects (Ctrl) at 0 (pretreatment), 7, and 24 h following sham depletion and tryptophan (TrpD) depletion conducted at least 8 days apart under balanced, randomized, blinded conditions. Immunoglobulins were measured by automated immunonephelometry. Data were analyzed by repeated measures ANOVA with diagnosis as a fixed effect and drug (TrpD vs. sham), and time as repeated measures factors. Serum IgA was consistently lower in ruMDD patients vs. Ctrl at all time points examined (p < 0.04 for main effect of diagnosis). Serum IgG and IgM levels did not show significant differences by diagnosis. Medication-free patients with major depression in the remitted state have a significant reduction in serum IgA levels measured on multiple occasions. In the light of the fact that IgA serves many immunomodulatory, anti-inflammatory roles, this finding supports the concept that major depressive illness represents a proinflammatory state.