Complement activation in Lyme neuroborreliosis — Increased levels of C1q and C3a in cerebrospinal fluid indicate complement activation in the CNS
- 作者：Anna J. Henningsson ; Jan Ernerudh ; Kerstin S ; holm ; Sten-Anders Carlsson ; Hans Granlund ; Christian Jansson ; Dag Nyman ; Pia Forsberg ; Kristina Nilsson Ekdahl
- 关键词：Complement ; Neuroborreliosis ; Inflammation ; Lyme borreliosis ; Cerebrospinal fluid
- 刊名：Journal of Neuroimmunology
- 出版年：2007
- 期刊代码：32_01655728
- 类别：neu
- 出版时间：February 2007
- 卷：183
- 期：1-2
- 页码：200-207
- 文件大小：242 K
摘要
A strong initial inflammatory response is important in neuroborreliosis. Since complement is a main player in early inflammation, we monitored the concentration and activation of complement in plasma and cerebrospinal fluid from 298 patients, of whom 23 were diagnosed with neuroborreliosis. Using sandwich ELISAs, we found significantly elevated levels of C1q, C4, C3, and C3a in cerebrospinal fluid, but not in plasma, in patients with neuroborreliosis. This finding indicates that complement plays a role in the human immune response in neuroborreliosis, that the immunologic process is compartmentalized to the CNS, and that complement activation may occur via the classical pathway.