Synthesis and evaluation of NO-release from symmetrically substituted furoxans
- 作者：William F. Nirode ; Jessica M. Luis ; Jordan F. Wicker and Nanette M. Wachter
- 关键词：Furoxan ; Nitrosothiol ; Nitric oxide
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2006
- 期刊代码：10_0960894x
- 类别：ch
- 出版时间：15 April 2006
- 卷：16
- 期：8
- 页码：2299-2301
- 文件大小：102 K
摘要
A series of symmetrically substituted dibenzoyl furoxans were synthesized and investigated for their potential to release nitric oxide, which plays a key role in the nervous and cardiovascular systems. Cysteine was employed to promote nitric oxide release from furoxan via the formation of an S-nitrosothiol intermediate. Transition metal ion-mediated S-nitrosocysteine decomposition liberates nitric oxide that, in aqueous aerobic solutions, is converted to reactive nitrogen oxide species. The percent nitric oxide released was quantified colorimetrically by the Griess reagent system.