Anthrax and the inflammasome

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• 作者：Mahtab Moayerip> ; p>p>mmoayeri@niaid.nih.govp> ; Inka Sastallap>1p>p> ; p>p>sastallai@niaid.nih.govp> ; Stephen H. Lepplap>1p>p> ; p>p>sleppla@niaid.nih.govp>
• 关键词：Anthrax lethal toxin ; Inflammasome ; Caspase-1 ; Nlrp1 ; Nlrp1b ; Bacillus anthracis
• 刊名：Microbes and Infection
• 出版年：2012
• 期刊代码：65_12864579
• 类别：imm
• 出版时间：May, 2012
• 卷：14
• 期：5
• 页码：392-400
• 文件大小：305 K

摘要

Anthrax lethal toxin (LT), a major virulence determinant of anthrax disease, induces vascular collapse in mice and rats. LT activates the Nlrp1 inflammasome in macrophages and dendritic cells, resulting in caspase-1 activation, IL-1尾 and IL-18 maturation and a rapid cell death (pyroptosis). This review presents the current understanding of LT-induced activation of Nlrp1 in cells and its consequences for toxin-mediated effects in rodent toxin and spore challenge models.