Suppressing background signals in solid state NMR via the Electronic Mixing-Mediated Annihilation (EMMA) method

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• 作者：Giulia Mollica^a ; Fabio Ziarelli^b ; ^{fabio.ziarelli@univ-amu.fr} ; Aura Tintaru^a ; Pierre Thureau^a ; Sté ; phane Viel^a
• 关键词：Background signal ; ERETIC&trade ; Signal suppression ; Solid state NMR ; Quantitative NMR
• 刊名：Journal of Magnetic Resonance
• 出版年：2012
• 期刊代码：126_10907807
• 类别：ch
• 出版时间：May, 2012
• 卷：218
• 期：Complete
• 页码：1-4
• 文件大小：389 K

摘要

A simple procedure to effectively suppress background signals arising from various probe head components (e.g. stator, rotors, inserts) in solid state NMR is presented. Similarly to the ERETIC鈩?method, which uses an electronic signal as an internal standard for quantification, the proposed scheme is based on an electronically generated time-dependent signal that is injected into the receiver coil of the NMR probe head during signal acquisition. More specifically, the line shape, width and frequency of this electronic signal are determined by deconvoluting the background signal in the frequency domain. This deconvoluted signal is then converted into a time-dependent function through inverse Fourier Transform, which is used to generate the shaped pulse that is fed into the receiver coil during the acquisition of the Free Induction Decay. The power of the shaped pulse is adjusted to match the intensity of the background signal, and its phase is shifted by 180掳 with respect to the receiver reference phase. This so-called Electronic Mixing-Mediated Annihilation (EMMA) methodology is demonstrated here with a ¹³C Single Pulse Magic Angle Spinning spectrum of an isotopically enriched ¹³C histidine solid sample recorded under quantitative conditions.