Copper-catalyzed enantioselective conjugate addition of diethylzinc using axially chiral aminoethyloxy-phosphine ligands

详细信息	查看全文 | 推荐本文 |

• 作者：Toshiaki Morimoto ; Nobuhiro Obara ; Iku Yoshida ; Kiyoshi Tanaka ; Toshiyuki Kan
• 刊名：Tetrahedron Letters
• 出版年：2007
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：23 April 2007
• 卷：48
• 期：17
• 页码：3093-3095
• 文件大小：122 K

摘要

New axially chiral P,O,N-type ligands bearing both a diphenylphosphino group and 2-(dialkylamino)ethyloxy (or 2-pyridylmethyloxy) groups were designed and prepared along with P,O,O-type ligands by employing an easily available chiral component, (R)-2-hydroxy-2′-diphenylphosphinyl-1,1′-binaphthyl. Among the ligands the simplest P,O,N-type one bearing a 2-(dimethylamino)ethyloxy group was found to be the most efficient in copper-catalyzed enantioselective conjugate addition of diethylzinc to a cyclic enone, 2-cyclohexen-1-one, providing high enantioselectivity up to 99%ee.