Synthesis, photophysics and photochemistry of phthalocyanine-蓻-polylysine conjugates in the presence of metal nanoparticles against Staphylococcus aureus

详细信息	查看全文 | 推荐本文 |

• 作者：Nolwazi Nombona ; Edith Antunes ; Wadzanai Chidawanyika ; Phumelele Kleyi ; Zenixole Tshentu ; Tebello Nyokong ; ^{t.nyokong@ru.ac.za}
• 关键词：Phthalocyanine ; 蓻-Polylysine ; Staphylococcus aureus ; Nanoparticles
• 刊名：Journal of Photochemistry and Photobiology A ; Chemistry
• 出版年：2012
• 期刊代码：66_10106030
• 类别：ch
• 出版时间：1 April, 2012
• 卷：233
• 期：Complete
• 页码：24-33
• 文件大小：1276 K

摘要

This work reports on the photodynamic activity of Zn phthalocyanine-蓻-polylysine conjugates in the presence of gold and silver nanoparticles (NPs) towards the inactivation of Staphylococcus aureus (S. aureus). The conjugates showed high photoinactivation with 鈭?%growth at a drug dose of 3 渭M and fluence of 39.6 mW/cm² for 10 min irradiation time in the presence of silver nanoparticles. The presence of silver nanoparticels from the minimal inhibition concentration (MIC₅₀) studies showed remarkable growth inhibition for the tested conjugates even at low concentrations. The MIC₅₀ was lowest for the conjugate of 3 with 蓻-polylysine at concentrations of less than 0.0058 渭M in the presence of AgNPs. The lethal photosensitization of microorganisms has emerged as a promising treatment since bacteria have reduced possibilities of developing resistance to photodynamic therapy.