4-Hydroxy-2-nonenal induces chronic obstructive pulmonary disease-like histopathologic changes in mice
- 作者：Takayuki Takimoto ; takataka2003@mail.goo.ne.jp ; Mitsuhiro Yoshida ; Haruhiko Hirata ; Yozo Kashiwa ; Yoshito Takeda ; Sho Goya ; Takashi Kijima ; Toru Kumagai ; Isao Tachibana ; Ichiro Kawase
- 关键词：Chronic obstructive pulmonary disease (COPD) ; Oxidative stress ; 4-Hydroxy-2-nonenal (4-HNE) ; Inflammation ; Matrix metalloprotease (MMP) ; Apoptosis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2012
- 期刊代码：159_0006291x
- 类别：bio
- 出版时间：30 March, 2012
- 卷：420
- 期：1
- 页码：84-90
- 文件大小：1651 K
摘要
The 伪,尾-unsaturated aldehyde 4-hydroxy-2-nonenal (4-HNE) is an endogenous product of oxidative stress that is found at increased levels in the lungs of patients with chronic obstructive pulmonary disease (COPD) and animal models of this lung disorder. In the present study, levels of 4-HNE adducts were increased in two different mouse models of COPD. Challenging lungs with 4-HNE enlarged the airspace and induced goblet cell metaplasia of the airways in mice, two characteristics of COPD. 4-HNE induced the accumulation of inflammatory cells expressing high levels of MMP-2 and MMP-9. Our results indicate that 4-HNE production during oxidative stress is a key pathway in the pathogenesis of COPD.