Formation of N^α-benzyloxycarbonyl--aminoadipic acid from N^α-benzyloxycarbonyl--lysine with mycelia from Aspergillus niger

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• 作者：Isobe ; Kimiyasu ; Tokuta ; Keigo ; Narita ; Yuuki ; Matsuura ; Akira ; Sakaguchi ; Takehiko ; Wakao ; Norio
• 关键词：N^α ; -Z-l-lysine ; N^α ; -benzyloxycarbonyl-l-lysine ; MBTH ; 3-methyl-2-benzothiazolinone hydrazone ; TOOS ; N-ethyl-N-(2-hydroxy-3-sulfopropyl)-3-methylaniline ; sodium salt ; dihydrate ; Amine oxidase ; Aspergillus niger ; N^α ;
• 刊名：Journal of Molecular Catalysis B ; Enzymatic
• 出版年：2004
• 期刊代码：55_13811177
• 类别：ce
• 出版时间：July 5, 2004
• 卷：30
• 期：1
• 页码：13-18
• 文件大小：105 K

摘要

A method for formation of N^α-benzyloxycarbonyl-l-aminoadipic acid (N^α-Z-l-AAA) was investigated. N^α-Z-l-AAA was formed from N^α-Z-l-lysine via N^α-Z-l-aminoadipate-δ-semialdehyde (N^α-Z-l-AASA) by the reaction with mycelia from Aspergillus niger according to Scheme 1. In this reaction, oxidation of N^α-Z-l-lysine to N^α-Z-l-AASA was catalyzed by amine oxidase. The reaction at pH 7.0 and 30°C was optimum for N^α-Z-l-AAA formation, and approximately 50%of the decomposed N^α-Z-l-lysine was converted into N^α-Z-l-AAA.