Rheumatoid lung disease: Prognostic analysis of 54 biopsy-proven cases

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• 作者：Yutaro Nakamura^a ; ^{nakayuta@hama-med.ac.jp} ; Takafumi Suda^a ; Yusuke Kaida^a ; Masato Kono^a ; Hironao Hozumi^a ; Dai Hashimoto^a ; Noriyuki Enomoto^a ; Tomoyuki Fujisawa^a ; Naoki Inui^a ; Shiro Imokawa^a ; Kazumasa Yasuda^a ; Toshihiro Shirai^a ; Hideki Suganuma^a ; Satoru Morita^a ; Hiroshi Hayakawa^a ; Yasuo Takehara^b ; Thomas V. Colby^c ; Kingo Chida^a
• 关键词：Connective tissue disease ; Rheumatoid arthritis ; Interstitial lung disease ; Histopathological diagnosis ; Prognosis
• 刊名：Respiratory Medicine
• 出版年：2012
• 期刊代码：273_09546111
• 类别：med
• 出版时间：August, 2012
• 卷：106
• 期：8
• 页码：1164-1169
• 文件大小：242 K

摘要

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Summary

Objective

To investigate the prognostic significance of histopathological characteristics in patients with biopsy-proven rheumatoid lung disease (RLD).

Materials and methods

Retrospective analysis was conducted on samples from 54 RLD patients who underwent surgical lung biopsies (SLBs) at Hamamatsu University Hospital and affiliated hospitals between 1980 and 2009. The overall survival rate, the spectrum of histopathological diagnosis and their associated prognostic significance were investigated.

Results

The study group consisted of 30 men and 24 women with a median age of 60.3 years. Histopathological analysis revealed the following: usual interstitial pneumonia (UIP), 15 cases; nonspecific interstitial pneumonia/fibrosis, 16 cases; organizing pneumonia, 4 cases; unclassifiable, 2 cases; desquamative interstitial pneumonia, 1 case; and bronchiolar disease, 16 cases. In survival outcome, 10聽yr survival rate was 76.6%. Patients with UIP had significantly worse prognosis than those with non-UIP (RLD cases except those with UIP) (p聽=聽0.0452).

Conclusion

RLD includes several histopathological groups. Patients with UIP have worse survival than those with other types of RLD. Histopathological diagnosis may have a major impact on prognostication in patients with RLD.