CD28−CD57+ T cells predominate in CD8 responses to glatiramer acetate
- 作者：Robert B. Ratts ; Amy E. Lovett-Racke ; Judy Choy ; Sara C. Northrop ; Rehana Z. Hussain ; Nitin J. Karandikar and Michael K. Racke
- 关键词：Human ; T cells ; Cytotoxic ; Autoimmunity ; Viral ; Cell differentiation
- 刊名：Journal of Neuroimmunology
- 出版年：2006
- 期刊代码：32_01655728
- 类别：neu
- 出版时间：September 2006
- 卷：178
- 期：1-2
- 页码：117-129
- 文件大小：879 K
摘要
Human T cells adopt a CD28−CD57+ phenotype in chronic viral infections and this has been hypothesized to result from continuous stimulation, however this phenotype may be due to direct viral effects on T cells. Employing MS patients before and after chronic in vivo administration of the antigen glatiramer acetate (GA) we examine this hypothesis. Pre-treatment glatiramer acetate-specific CD8 T cells were CD57−Perforin−. This changed to a predominantly CD28−CD57+Perforin+ response after administration of this drug. This phenotype was only observed after chronic stimulation and not in a recall response to mumps. The relevance to GA's mechanism of action is discussed.