D₄ receptor deficiency in mice has limited effects on impulsivity and novelty seeking

详细信息	查看全文 | 推荐本文 |

• 作者：C.M. Helms ; N.R. Gubner ; C.J. Wilhelm ; S.H. Mitchell ; D.K. Gr ; y
• 关键词：Impulsivity ; D₄ receptors ; Mice ; Delay discounting ; Go/No-go ; Inhibition ; Novelty seeking ; Locomotion
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：2008
• 期刊代码：219_00913057
• 类别：med
• 出版时间：September 2008
• 卷：90
• 期：3
• 页码：387-393
• 文件大小：382 K

摘要

Alleles of the human dopamine D₄ receptor (D₄R) gene (DRD4.7) have repeatedly been found to correlate with novelty seeking, substance abuse, pathological gambling, and attention-deficit hyperactivity disorder (ADHD). If these various psychopathologies are a result of attenuated D₄R-mediated signaling, mice lacking D₄Rs (D₄KO) should be more impulsive than wild-type (WT) mice and exhibit more novelty seeking. However, in our study, D₄KO and WT mice showed similar levels of impulsivity as measured by delay discounting performance and response inhibition on a Go/No-go test, suggesting that D₄R-mediated signaling may not affect impulsivity. D₄KO mice were more active than WT mice in the first 5 min of a novel open field test, suggesting greater novelty seeking. For both genotypes, more impulsive mice habituated less in the novel open field. These data suggest that the absence of D₄Rs is not sufficient to cause psychopathologies associated with heightened impulsivity and novelty seeking.