High novelty-seeking predicts greater sensitivity to the conditioned rewarding effects of cocaine
- 作者：Antonio Vidal-Infer ; M. Carmen Arenas ; Manuel Daza-Losada ; Mª ; . Asunció ; n Aguilar ; José ; Miñ ; arro ; Marta Rodrí ; guez-Arias ; marta.rodriguez@uv.es
- 关键词：Cocaine ; CPP ; Novelty-seeking ; Adolescence ; Mice
- 刊名：Pharmacology Biochemistry and Behavior
- 出版年：2012
- 期刊代码：219_00913057
- 类别：med
- 出版时间：July, 2012
- 卷：102
- 期：1
- 页码：124-132
- 文件大小：622 K
摘要
Novelty-seeking in rodents, defined as enhanced specific exploration of novel situations, is considered to predict the response of animals to drugs of abuse and, thus, identify 鈥渄rug-vulnerable鈥?individuals. The main objective of this work was to determine the capacity of two animal models鈥攖he novel object recognition task and the novel environment test鈥攆or evaluating to what extent novelty-seeking can predict greater sensitivity to the rewarding properties of cocaine in young adult (PND 56) and adolescent (PND 35) OF1 mice of both sexes. Conditioned place preference, a useful tool for evaluating the sensitivity of individuals to the incentive properties of addictive drugs, was induced with a sub-threshold dose of cocaine (1 mg/kg, i.p.). Three factors that predispose individuals to addiction were considered: age, sex and novelty-seeking trait. CPP was detected only in the young adults that spent most time exploring the novel environment (High Novel Environment Seekers, High-Environment-NS). The novel environment test seemed to be more effective than the novel object recognition task in identifying young adults vulnerable to drugs; specifically, it revealed a distinction between High- and Low-Environment-NS mice that predicted greater sensitivity to the rewarding properties of cocaine among young adults but not among adolescents. Although our results reveal a higher novelty preference among young adult females than among their male counterparts in the two NS tests, both sexes showed similar susceptibility to the rewarding effects of a sub-threshold dose of cocaine in the CPP. These findings suggest that screening can identify humans at-risk of becoming drug users, and may contribute to the development of prevention strategies based on specific vulnerabilities.