G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke
- 作者：Hidenori Hattori ; Akira Sonoda ; Hideki Sato ; Daisuke Ito ; Norio Tanahashi ; Mitsuru Murata ; Ikuo Saito ; Kiyoaki Watanabe ; Norihiro Suzuki
- 关键词：Atherosclerosis ; Ischemic stroke ; Oxidized low-density lipoprotein receptor 1 ; Oxidized LDL ; Polymorphism ; Single nucleotide primer extension
- 刊名：Brain Research
- 出版年：2006
- 期刊代码：8_00068993
- 类别：neu
- 出版时间：22 November 2006
- 卷：1121
- 期：1
- 页码：246-249
- 文件大小：202 K
摘要
The human lectin-like oxidized low-density lipoprotein receptor 1 (OLR1/LOX-1) is the major endothelial scavenger receptor against oxidized low-density lipoprotein (Ox-LDL), which has been implicated in the pathogenesis of atherosclerosis. We investigated the G501C mutation in the OLR1 gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 274 age- and sex-matched healthy controls using single nucleotide primer extension analysis (SNuPe). There was no significant difference in the polymorphism between patients with ischemic CVD and controls (GC + CC versus GG, p = 0.48). The C allele was not significantly different between the patients and controls (C versus G, p = 0.91). Our results show that the OLR1 gene polymorphism has little effect on an increased risk for ischemic CVD in the Japanese population.