The combined contraceptive vaginal ring, NuvaRing®, and tampon co-usage

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• 作者：Verhoeven ; Carole H.J. ; Dieben ; Th.O.M.
• 关键词：Contraceptive ; Co-usage ; Efficacy ; Ethinylestradiol ; Etonogestrel ; Tampon
• 刊名：Contraception
• 出版年：2004
• 期刊代码：71_00107824
• 类别：med
• 出版时间：March, 2004
• 卷：69
• 期：3
• 页码：197-199
• 文件大小：54.8 K

摘要

We investigated the effect of tampon co-usage on systemic exposure to etonogestrel (ENG) and ethinylestradiol (EE) from the combined contraceptive vaginal ring, NuvaRing®. One cycle of ring use consists of 3 weeks of ring use followed by a 1-week ring-free period. Fourteen healthy women were randomized to use both NuvaRing and tampons (Kotex® regular) or NuvaRing alone for one cycle; participants then switched to the alternate treatment regimen for a second cycle of ring use. The first tampon was self-administered on day 8 of the interaction cycle; 4 tampons a day were used for 3 consecutive days. Tampon co-usage did not result in any changes in serum ENG or EE concentrations and is thus not expected to compromise the ring's contraceptive efficacy.