• 作者：Sergio Raposeiras-Roubí ; n^a ; Bruno K. Rodiñ ; o-Janeiro^b ; Lilian Grigorian-Shamagian^a ; ^c ; Marí ; a Moure-Gonzá ; lez^a ; Ana Seoane-Blanco^a ; Alfonso Varela-Romá ; n^a ; Ezequiel Á ; lvarez^b ; ^d ; ^{ezequiel.alvarez@usc.es} ; José ; R. Gonzá ; lez-Juanatey^a ; ^b ; ^d
• 关键词：Productos finales de glicaci&oacute ; n avanzada ; Insuficiencia cardí ; aca cr&oacute ; nica ; Insuficiencia renal ; Enfermedad renal oculta
• 刊名：Medicina Cl铆nica
• 出版年：2011
• 期刊代码：pca254_00257753
• 类别：med
• 出版时间：30 April 2011
• 卷：136
• 期：12
• 页码：513-521
• 文件大小：300 K

Background and objectives

Advanced glycation end-products (AGE) are implicated in the physiopathology and prognosis of heart failure (HF) and they accumulate in situations such as kidney failure (KF). Our objective was to analyze the relation between AGE and KF in patients with chronic HF.

Materials and methods

102 consecutive patients of our medical center were included. Clinical and analytical data were obtained, with measurement of glycated haemoglobin, brain natriuretic peptide, cystatin C and fluorescent AGE. Glomerular filtration rate (GFR) was estimated for each patient.

Results

40.2%of patients presented GFR < 60 mL/min/1.73m² and 11.7%had hidden kidney disease (HKD). AGE correlated positively with creatinine (r = 0.685, p < 0.001) and cystatin C (r = 0.682, p < 0.001) and negatively with GFR (r = 鈭?.720, p < 0.001). Medium value of fluorescent AGE in patients with KF was higher than those without KF (83.4 [3.3] URF vs 56.8 [2.1] URF, p < 0.001). With regard to the diagnostic value for HKD, fluorescent AGE presented an area under the ROC curve higher than other parameters for KD such as cystatin C. In the multivariate analysis, fluorescent AGE were an independent biomarker of KD (OR 1.060; 95%CI 1.024-1.097; p = 0.001).

Conclusions

AGE act as a biomarker of KD in patients with chronic HF, both diabetics and non diabetics, being better than cystatin C in the detection of HKD.