Association of the intronic polymorphism rs891512 (G24943A) of the endothelial nitric oxide synthase gene with hypertension in Chilean type 2 diabetes patients

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• 作者：D. Seelenfreund<sup>asup><sup> ; sup><sup>dseelen@ciq.uchile.clsup> ; S.R. Lobos<sup>asup> ; A. Quesada<sup>asup> ; J.M. Saavedra<sup>asup> ; C. Wolff<sup>bsup> ; G. L&oacute ; pez-Stewart<sup>csup> ; A.V. Araya<sup>csup> ; P. Durruty<sup>bsup><sup> ; sup><sup>csup><sup> ; sup><sup>pdurruty@med.uchile.clsup>
• 关键词：NOS3 ; Polymorphism ; Hypertension ; Diabetes mellitus type 2 ; Splicing factor SF2/ASF
• 刊名：Diabetes Research and Clinical Practice
• 出版年：2012
• 期刊代码：78_01688227
• 类别：med
• 出版时间：May, 2012
• 卷：96
• 期：2
• 页码：e47-e49
• 文件大小：197 K

摘要

We investigated two single nucleotide polymorphisms of the NOS3 gene in type 2 diabetic patients (n = 93) and healthy non-diabetic controls (n = 76) and their relationship with smoking habits, body mass index, hypertension and dyslipidemia. Results showed that eNOS polymorphism rs891512 (G24943A) is associated with hypertension in Chilean individuals (p < 0.05).