Variation in the BDNF Val66Met polymorphism and response to cognitive-behavior therapy in obsessive-compulsive disorder

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• 作者：M.A. Fullana^a ; ^b ; ^{Miguel.Fullana@kcl.ac.uk} ; P. Alonso^c ; ^d ; ^e ; M. Gratacò ; s^f ; ^g ; N. Jaurrieta^c ; S. Jimé ; nez-Murcia^c ; ^e ; C. Segalà ; s^c ; E. Real^h ; X. Estivill^f ; ^g ; ⁱ ; ^j ; J.M. Mench&oacute ; n^c ; ^d ; ^e
• 关键词：Obsessive-compulsive disorder ; Extinction ; Cognitive-behavior therapy ; Genetics ; BDNF ; Val66Met
• 刊名：European Psychiatry
• 出版年：2012
• 期刊代码：96_09249338
• 类别：med
• 出版时间：July, 2012
• 卷：27
• 期：5
• 页码：386-390
• 文件大小：306 K

摘要

Background

Recent research suggests that the brain-derived neurotrophic factor (BDNF) may play a role in extinction learning. The goal of this study was to test whether variation in the BDNF Val66Met polymorphism is related to treatment response to exposure-based cognitive-behavior therapy (CBT), a form of extinction learning, in obsessive-compulsive disorder (OCD).

Methods

One hundred and six OCD patients from a specialized clinic, who underwent a standardized CBT treatment after partial or non-response to a 12-week pharmacological trial, were genotyped for the BDNF Val66Met and the relationship between genotype and treatment response was analyzed.

Results

Among 98 CBT completers, 36%of those carrying the BDNF Met allele were rated as CBT responders compared to 60%of nonMet allele carriers (m>Pm> = 0.027). When analyzing the different obsessive-compulsive symptom dimensions, in patients with contamination/cleaning symptoms, the Met allele was associated with a significantly worse CBT response (m>Pm> < 0.0001) and a lower obsessions severity decrease from pre- to posttreatment (m>Pm> = 0.046).

Conclusion

Genetic variation in BDNF may be associated with treatment response in exposure-based CBT in OCD, especially in those patients exhibiting contamination/cleaning symptoms.