• 作者：Ma Asunció ; n Recasens^a ; Celia Puig^a ; Vera Ortiz-Santamaria^b ; ^{33144vos@comb.cat}
• 关键词：Esclerosis sisté ; mica ; Nutrici&oacute ; n ; Dietista ; Desnutrici&oacute ; n ; Tracto gastrointestinal ; Abordaje terapé ; utico ; Malnutrici&oacute ; n
• 刊名：Reumatolog铆a Cl铆nica
• 出版年：2012
• 期刊代码：pca303_1699258X
• 类别：med
• 出版时间：May-June, 2012
• 卷：8
• 期：3
• 页码：135-140
• 文件大小：397 K

Systemic sclerosis is a connective tissue disease characterized by inflammation and fibrosis of multiple organs (skin, gastrointestinal tract, lung, kidney and heart). After the skin, the organ most affected with a frequency of 75 to 90%, the gastrointestinal tract is more often involved.

Gastrointestinal tract involvement is manifested by the appearance of oropharyngeal dysphagia, esophageal dysphagia, gastroesophageal reflux, gastroparesis, pseudo-obstruction, bacterial overgrowth and intestinal malabsorption, constipation, diarrhea and/or fecal incontinence. These effects influence food intake and intestinal absorption leading to the gradual emergence of nutritional deficiencies. About 30%of patients with systemic sclerosis are at risk of malnutrition. In 5-10%, gastrointestinal disorders are the leading cause of death.

Therapeutic strategies currently available are limited and aimed at reducing clinical symptoms. The multidisciplinary management of these patients, including nutritional intervention, helps improve gastrointestinal symptoms, and avoid malnutrition, morbidity and improve quality of life.