• 作者：Cristina Represas Represas^a ; ^b ; ^d ; Maribel Botana Rial^a ; ^b ; ^d ; Virginia Leiro Ferná ; ndez^a ; ^b ; ^d ; Ana Isabel Gonzá ; lez Silva^a ; ^b ; ^d ; Ví ; ctor del Campo Pé ; rez^c ; ^d ; Alberto Ferná ; ndez-Villar^a ; ^b ; ^d ; ^{alberto.fernandez.villar@sergas.es}
• 关键词：FEV6 ; Espirometrí ; a ; Cribado ; Enfermedad pulmonar obstructiva cr&oacute ; nica
• 刊名：Archivos de Bronconeumolog铆a
• 出版年：2010
• 期刊代码：pca65_03002896
• 类别：med
• 出版时间：August 2010
• 卷：46
• 期：8
• 页码：426-432
• 文件大小：489 K

Objectives

To evaluate the agreement and the association with FEV₁, FEV₆ and FEV₁/FEV₆ measured with the Vitalograph-COPD-6 portable device and the FEV₁, FVC and FEV₁/FVC by conventional spirometry, and to analyse the validity of this device to detect obstruction.

Methodology

A cross-sectional, descriptive, prospective study, that included 180 subjects. A conventional spirometry and one with the Vitalograph-COPD-6 were sequentially performed on them. The agreement was analysed [kappa index and interclass correlation coefficient (ICC)], as well as the association [Pearson correlation coefficient (r)], area under the ROC curve (AUC) of the FEV₁/FEV₆ in detecting obstruction, and the sensitivity, specificity, predictive values (PPV and NPV), and probability ratios (PR+ and PR-) of the different FEV₁/FEV₆ cut-off points in the detection of obstruction.

Results

The prevalence of obstruction was 47%. The kappa index was 0.59 when an FEV₁/FEV₆ < cut-off point of <0.7 was used. The ICC and the r between the FEV₁ measured by the two instruments, FEV₆ and FEV₁/FEV₆ measured by the Vitalograph-COPD-6 and the FVC and FEV₁/FVC determined by the spirometer were all greater than 0.92. The ROC AUC was 0.97. To detect obstruction, if the cut-off point of FEV₁/FEV₆ (for COPD-6) was <0.70, the sensitivity, specificity, PPV, NPV, CR+ and CR鈭?were, 58%, 100%, 100%, 73%, 鈭?and 0.42, respectively. For a cut-off point of <0.8, they were 96%, 76%, 78%, 96%, 3.8 and 0.05, respectively.

Conclusions

The portable Vitalograph-COPD6 device is precise for the detection of airway obstruction. The best sensitivity/specificity of FEV₁/FEV₆ was obtained with cut-off points greater than 0.7.