Development of an efficient and selective radioligand for bradykinin B₁ receptor occupancy studies

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• 作者：Su ; Dai-Shi ; Markowitz ; M. Kristine ; Murphy ; Kathy L. ; Wan ; Bang-Lin ; Zrada ; Matthew M. ; Harrell ; C. Meacham ; et. al.
• 关键词：Bradykinin B₁ receptor ; Antagonist ; Radioligand ; Ex vivo
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2004
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：December 20, 2004
• 卷：14
• 期：24
• 页码：6045-6048
• 文件大小：272 K

摘要

We have developed an efficient and selective radioligand, the [³⁵S]-radiolabeled dihydroquinoxalinone derivative, 4, for an ex vivo receptor occupancy assay in transgenic rats over-expressing the human bradykinin B₁ receptor.