2-5A Antisense Directed against Telomerase RNA Produces Apoptosis in Ovarian Cancer Cells

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• 作者：Kushner ; David M. ; Paranjape ; Jayashree M. ; Bandyopadhyay ; Bhaswati ; Cramer ; Hagen ; Leaman ; Douglas W. ; et. al.
• 刊名：Gynecologic Oncology
• 出版年：2000
• 期刊代码：295_00908258
• 类别：med
• 出版时间：February, 2000
• 卷：76
• 期：2
• 页码：183-192
• 文件大小：238 K

摘要

Objective. RNase L is converted to an active form upon binding short 2′,5′-oligoadenylates (2-5A). To direct RNase L to an RNA target, 2-5A is attached to an antisense oligonucleotide (2-5A antisense). This chimera can be directed against telomerase—an RNA–protein complex that elongates telomeric DNA and is involved in cellular immortalization. Our objective is to investigate the effect of 2-5A antisense by targeting telomerase RNA (hTR) in the ovarian cancer cell line, HEY-1B.