A scientific journey through the 2-5A/RNase L system
- 作者：Robert H. Silverman
- 关键词：2-5A ; RNase L ; Interferon ; Cancer ; Virus
- 刊名：Cytokine and Growth Factor Reviews
- 出版年：2007
- 期刊代码：62_13596101
- 类别：bio
- 出版时间：October-December 2007
- 卷：18
- 期：5-6
- 页码：381-388
- 文件大小：757 K
摘要
The antiviral and antitumor actions of interferons are caused, in part, by a remarkable regulated RNA cleavage pathway known as the 2-5A/RNase L system. 2′-5′ linked oligoadenylates (2-5A) are produced from ATP by interferon-inducible synthetases. 2-5A activates pre-existing RNase L, resulting in the cleavage of RNAs within single-stranded regions. Activation of RNase L by 2-5A leads to an antiviral response, although precisely how this happens is a subject of ongoing investigations. Recently, RNase L was identified as the hereditary prostate cancer 1 gene. That finding has led to the discovery of a novel human retrovirus, XMRV. My scientific journey through the 2-5A system recounts some of the highlights of these efforts. Knowledge gained from studies on the 2-5A system could have an impact on development of therapies for important viral pathogens and cancer.