Modification of fibrous poly(l-lactic acid) scaffolds with self-assembling triblock molecules
- 作者：Stendahl ; John C. ; Li ; Leiming ; Claussen ; Randal C. ; Stupp ; Samuel I.
- 关键词：Cell adhesion ; Polylactic acid ; Scaffold ; Self-assembly ; Surface modification
- 刊名：Biomaterials
- 出版年：2004
- 期刊代码：7_01429612
- 类别：ms
- 出版时间：December, 2004
- 卷：25
- 期：27
- 页码：5847-5856
- 文件大小：572 K
摘要
Molecular self-assembly offers an effective method to modify the surface properties of common biomaterials by presenting biologically relevant chemistry in a controlled, ordered fashion. This work reports on self-assembling triblock molecules containing rigid cholesteryl segments followed by flexible oligomers of l-(lactic acid) and second generation l-lysine dendrons. Second harmonic generation and small angle X-ray scattering indicate these molecules self-assemble into multilayer polar structures when cast from ethyl acetate solutions and segregate into polar polydomains when annealed. These self-assembled layers significantly improve water wettability when coated onto poly(l-lactic acid) fibers. Scaffolds formed from fibers modified by self-assembly enhance adhesion of 3T3 mouse calvaria cells and produce greater population growth rates. These results demonstrate the use of self-assembly to present biologically relevant chemistry on surfaces of biomaterials. Applications of this technology include the modification of substrates for cell culture, tissue engineering, and cell transplantation.