Association between the rs2910164 polymorphism in pre-mir-146a and oral carcinoma progression

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• 作者：Pei-Shi Hung^a ; ^d ; Kuo-Wei Chang^a ; ^b ; ^d ; Shou-Yen Kao^a ; ^b ; Ting-Hui Chu^a ; Chung-Ji Liu^a ; ^c ; Shu-Chun Lin^a ; ^b ; ^{sclin@ym.edu.tw}
• 关键词：Carcinoma ; MicroRNA ; miR-146a ; Mouth ; Polymorphism
• 刊名：Oral Oncology
• 出版年：2012
• 期刊代码：213_13688375
• 类别：med
• 出版时间：May, 2012
• 卷：48
• 期：5
• 页码：404-408
• 文件大小：305 K

摘要

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Summary

MicroRNAs are short non-coding RNAs that regulate gene expression by RNA interference. Oral squamous cell carcinoma (OSCC) is a prevalent malignancy worldwide. miR-146a has been reported to regulate Toll-like receptors and cytokine signaling, which are both crucial for inflammation and oncogenesis. This study identifies that areca nut extract, TNF伪 and TGF尾 up-regulates miR-146a in OSCC cells. The increased expression of miR-146a enhanced the oncogenicity of OSCC cells. In addition, a G to C polymorphism (rs2910164), which is located in the pre-miR-146a and has been associated with functional alterations in miR-146a, was significantly more prevalent among OSCC patients having more advanced nodal involvement. Our analysis also suggested a higher miR-146a expression in OSCC tissues of patients carrying C polymorphism. The present study concluded a higher prevalence of the pre-mir-146a C-variant was associated with OSCC progression in patients with this disease.