A 13-week subchronic toxicity study of dietary administered morin in F344 rats
- 作者：Y.-M. Cho ; H. Onodera ; M. Ueda ; T. Imai and M. Hirose
- 关键词：Morin ; F344 rats ; Subchronic toxicity
- 刊名：Food and Chemical Toxicology
- 出版年：2006
- 期刊代码：20_02786915
- 类别：pha
- 出版时间：June 2006
- 卷：44
- 期：6
- 页码：891-897
- 文件大小：125 K
摘要
A subchronic toxicity study of a flavonoid morin was performed in both sexes of F344 rats with dietary administration at concentrations of 0%, 0.625%, 1.25%, 2.5%and 5%(w/w) for 13 weeks. No mortality or abnormal clinical signs were observed throughout the experimental period in any group. Although a slight tendency for increase in food intake was noted in both sexes of the 2.5%and 5.0%groups, slight non-significant body weight decrease was observed in 5.0%males. Significant increases in alanine transaminase (ALT; over 2.5%), alkali phosphatase (ALP; 1.25%and 5.0%) and relative liver weights (1.25%and 2.5%) in males and in γ-glutamyl transpeptidase (γ-GT), aspartate transaminase (AST), ALT, relative liver weights in the 2.5%and 5.0%females and ALP in 5.0%females were noted. Increased urea nitrogen and relative kidney weights at dose of 1.25%and above and creatinine at 5.0%were observed also in females. On histopathological observation, hepatocyte hypertrophy was detected in 3 of 10 5.0%females. Based on the above findings, the no-observed-adverse-effect level (NOAEL) for both sexes was estimated to be 0.625%(299 and 356 mg/kg b.w./day for males and females, respectively).