Copper complex catalyzed asymmetric monosulfonylation of meso-vic-diols

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• 作者：Yosuke Demizu ; Kazuya Matsumoto ; Osamu Onomura ; Yoshihiro Matsumura
• 关键词：Asymmetric desymmetrization ; meso-vic-Diol ; Sulfonylation ; Copper complex
• 刊名：Tetrahedron Letters
• 出版年：2007
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：22 October 2007
• 卷：48
• 期：43
• 页码：7605-7609
• 文件大小：156 K

摘要

Asymmetric desymmetrization of meso-vic-diols was performed by tosylation in the presence of copper(II) triflate and (R,R)-Ph-BOX as a catalyst. The method was successfully applied to asymmetric desymmetrization of cyclic and acyclic meso-vic-diols in high enantioselectivity with up to >99%ee.