- 作者：Farzad Deyhim ; Arnulfo Villarreal ; Kristi Garcia ; Ryan Rios ; Claudia Garcia ; Cheri Gonzales ; Kranthi M ; adi ; Bhimanagouda S. Patil
- 关键词：Oxidative stress ; Orange pulp ; Antioxidants ; C-reactive protein ; Lipid profile ; Orchidectomy
- 刊名：Nutrition
- 出版年：2007
- 期刊代码：81_08999007
- 类别：abs
- 出版时间：July-August 2007
- 卷：23
- 期：7-8
- 页码：617-621
- 文件大小：90 K
Methods
In the present study, 45 1-y-old male rats were randomized to a sham-control group (n = 9) and an orchidectomized group (n = 36). The orchidectomized group was equally divided among the following five treatments: orchidectomy (ORX), ORX + 2.5%OP, ORX + 5%OP, and ORX + 10%OP. One hundred twenty days after the study began, all rats were sacrificed and plasma was harvested for its antioxidant status, C-reactive protein (CRP), lipid profile, and indices of peroxidation. Superoxide dismutase (SOD) and catalase activities in the liver were also monitored.
Results
Orchidectomy decreased (P < 0.05) plasma levels of antioxidant, SOD, catalase, and CRP and increased (P < 0.05) plasma levels of malondialdehyde, nitrite, and lipid profile compared with the sham-control group. In contrast to ORX, ORX + OP increased (P < 0.05) plasma antioxidant, dose-dependently increased (P < 0.05) SOD and catalase, decreased (P < 0.05) plasma malondialdehyde, nitrite, cholesterol, and triacylglycerol concentrations in the liver; and had no effect (P > 0.1) on plasma CRP or lipid profiles.
Conclusion
The beneficial effect of eating an orange is demonstrated by the increasing antioxidant status and by the decreasing peroxidation independent of plasma triacylglycerol, cholesterol, or CRP concentrations.