Retinoid-related orphan receptor alpha and the regulation of lipid homeostasis
- 作者：Rebecca L. Fitzsimmons ; Patrick Lau ; George E.O. Muscat ; g.muscat@imb.uq.edu.au
- 关键词：Nuclear hormone receptor ; ROR伪 ; Metabolism ; Staggerer ; Lipogenesis ; Lipoprotein metabolism
- 刊名：The Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2012
- 期刊代码：172_09600760
- 类别：med
- 出版时间：July, 2012
- 卷：130
- 期：3-5
- 页码：159-168
- 文件大小：525 K
摘要
Many nuclear hormone receptors (NRs) control lipid, glucose and energy homeostasis in an organ specific manner. Concordantly, dysfunctional NR signalling results in metabolic disease. The Retinoic acid receptor-related orphan receptor alpha (ROR伪), a member of the NR1F subgroup, is expressed in metabolic tissues. Previous studies identified the role of this NR in dyslipidemia, apo-lipoprotein metabolism and atherosclerosis. Recent data is underscoring the significant role of this orphan NR in the regulation of phase I/II metabolism (bile acids, xenobiotics, steroids etc.), adiposity, insulin signalling, and glucose tolerance. Moreover, oxygenated sterols, have been demonstrated to function as native ligands and inverse agonists. This review focuses on the rapidly emerging and evolving role of ROR伪 in the control of lipid and glucose homeostasis in major mass metabolic tissues.
Article from the special issue orphan receptors.